SWOG clinical trial number
S0022

Phase II Trial of Concurrent Cisplatin/Docetaxel and Radiotherapy Followed by Consolidation Docetaxel in Stage IIIB Non-Small Cell Lung Cancer

Closed
Phase
Accrual
33%
Abbreviated Title
Cis/Doc/RT followed by Consolidation Doc in NSCLC; Stage IIIB
Activated
03/15/2001
Closed
02/01/2003
Participants
NCORP, Members, Medical Oncologists, Radiation Oncologists

Research committees

Lung Cancer

Treatment

Cisplatin Docetaxel Radiation Therapy

Eligibility Criteria Expand/Collapse

Patients must have either hist. or cyto. proven newly diagnosed Stage IIIB (N3 or T4) single, primary bronchogenic non-small cell lung cancer (adenocarcinoma, non-lobar and non-diffuse bronchioloalveolar cell carcinoma, large cell carcinoma, or squamous cell carcinoma). Histology or cytology from involved mediastinal or supraclavicular lymph nodes alone will be allowed if a separate distal primary lesion is clearly evident on radiographs (i.e., a second biopsy will not be required); pts. with any brain mets are ineligible (all patients must have a pretreatment CT or MRI of the brain to evaluate for CNS disease); pts. with two or more parenchymal lesions on same or opposite sides of the lung are ineligible; pts. with malignant pleural effusions or with pericardial effusions are ineligible; pts. must have measurable or non-measurable disease (per Section 1.1) documented by CT, MRI, X-ray or physical exam. Measurable disease must be assessed w/in 28 days prior to registration, non-measurable disease assessed w/in 42 days prior to registration; pts. must not have received any prior chemotherapy or radiotherapy for lung cancer; pts. must not have had a previous surgical resection; however, patients may have undergone exploratory thoracotomy, mediastinoscopy, excisional biopsy or similar surgery for the purpose of determining diagnosis, stage, or potential resectability of newly diagnosed lung tumor; pts. preregistration FEV1 must be either >= 2.0 liters, if < 2.0 liters, then the predicted FEV1 of the contralateral lung must be > 800 cc based on the quantitative split function testing (predicted FEV1 = FEV1 x % perfusion to uninvolved lung from quantitative lung V/Q scan report) OR the predicted post-treatment FEV1 is judged by the radiation oncologist to be >= 1 liter.

Publication Information Expand/Collapse

2016

Comorbidities and Risk of Chemotherapy-Induced Peripheral Neuropathy Among Participants 65 Years or Older in Southwest Oncology Group Clinical Trials

D Hershman;C Till;J Wright;D Awad;S Ramsey;W Barlow;L Minasian;J Unger Journal of Clinical Oncology Sep 1;34(25):3014-3022; 2016 Jun 20 [Epub ahead of print]

PMid: PMID27325863 | PMC number: PMC5012713

Comorbidities and risk of chemotherapy induced peripheral neuropathy among participants in SWOG clinical trials

DL Hershman;C Till;JD Wright;D Awad;S Ramsey;W Barlow;L Minasian;J Unger Journal of Clinical Oncology 34, 2016 (suppl; abstr 10001); American Society of Clinical Oncology Annual Meeting (June 3-7, 2016, Chicago, IL), oral presentation

Other Clinical Trials

SWOG Clinical Trial Number
S2414

INcorporating pathologic reSponse in patIents with early staGe lung cancer to optimize immunotHerapy in the adjuvanT setting (INSIGHT)

Research Committee(s)
Lung Cancer
Symptom Control and Quality of Life
Activated
03/14/2025
Accrual
1%
Open
Phase
SWOG Clinical Trial Number
CTSU/NRG-LU007