SWOG clinical trial number
S0122

Phase II Trial of Patients with Limited Stage Small Cell Lung Cancer Treated with Thoracic Radiation Therapy and Chemotherapy with Cisplatin/Etoposide Followed by Cisplatin/Etoposide and Anti-Idiotype Monoclonal Antibody Vaccines

Closed
Phase
Accrual
10%
Abbreviated Title
Cisplat/Etopo/RT followed by Cisplat/Etopo/TriAb & TriGem Vaccines in Limited SCLC
Activated
12/15/2002
Closed
05/15/2003
Participants
NCORP, Members, Medical Oncologists, Radiation Oncologists

Research committees

Lung Cancer

Treatment

Cisplatin Etoposide TriAb TriGem RT

Eligibility Criteria Expand/Collapse

Pts must have histologically/cytologically-confirmed limited SCLC (diagnosis based on sputum is acceptable); evidence of dz by Chest CT; >/= 2 weeks from surgery and recovered (dz must be present outside the area of surgical resection); pts must be willing to participate in immune studies; FEV1 and DLCO obtained; ANC >/= 1,500; PLTS >/= 100,000; PS 0-1; serum creatinine </= IULN or CrCl >/= 60 cc/min (meas. or calc.); 18 yrs or older; no other prior malignancy except: treated basal cell or squamous cell skin ca, in situ cervical ca, Stage I or II ca in complete remission (disease-free from any ca for 5 yrs.); pts with malignant pericardial or pleural effusions are not eligible; pts must not have had prior chemo, thoracic RT or biologic tx for SCLC; pts must not have received prior TriAb/TriGem or have a hx of sensitivity; pts must not have known exposure to murine antibodies or known sensitivity to rodent proteins; pts must not have CNS dz by CT or MRI of brain; pts must not have received investigational device/agent, immunotherapy, immunization or systemic corticosteroids (except as part of anti-emetic regimen) w/in 30 days or must not be planning to receive systemic corticosteroids or other immunosuppressants, etc.; pts must not have >/= Grade 1 symptomatic neuropathy-sensory; pts must not be hearing impaired and unwilling to accept further worsening; pts must not be pregnant or nursing or of reproductive potential and not agreed to use of effective contraceptive method.

Other Clinical Trials

SWOG Clinical Trial Number
S2414

INcorporating pathologic reSponse in patIents with early staGe lung cancer to optimize immunotHerapy in the adjuvanT setting (INSIGHT)

Research Committee(s)
Lung Cancer
Symptom Control and Quality of Life
Activated
03/14/2025
Accrual
1%
Open
Phase
SWOG Clinical Trial Number
CTSU/NRG-LU007